This research was spearheaded by Michael Karin. Willscott Naugler who was the initial author of this paper, expressed their speculation whether an augmented inflammation was the reason behind the elevated occurrence of cancer of the liver in males.  What comprises the bulk of the cancer of the liver in human beings was heptocellular carcinoma or HCC. The latter was regarded to be a demoralizing impediment of unceasing disease of the liver as well as the inflammation which was a consequence of risk factors namely the viruses of hepatitis B as well as C. Alcoholic disease of the liver was also included in the major factors. Generally, men have a higher degree of acquiring the disease than do women. Furthermore, for those people who were not over fifty years old, HCC was noticed to have a higher likelihood of developing. The original text conveyed that it was calculated to be between seven up to ten times more. Moreover, a well-defined gender discrepancy was also observed in mice.
                                                                           
        To be able to grasp a better understanding on the mechanisms behind the disparity of gender in HCC, a chemical carcinogen called DEN was employed to stimulate the cancer in mice. There were a number of information that was derived from this experiment. It had also been found out that the female mice that were offered DEN had a smaller amount of IL-6 compared to the males.
Karin expressed that elimination of the IL-6 the occurrence of cancer of the liver for males were reduced by a percentage closer to ninety percent. What was important to be taken note was that the vanished IL-6 for the female mice did not make any further difference.

        The experiment also included the treatment of estrogen to male mice and the exposure of such to DEN. It was revealed that the level of IL- 6 for the males was decreased to an equivalent level just like those of the female. This was the same with the degree of injury of the liver. This same mechanism might be the reason behind the sexual category bias for acquiring cancer of the liver for human beings. Needless to say, with the experiment and its findings, remedies could be possibly developed in order to decrease the advancement of cancer of the liver for the males. This could be done by either of three ways. First, the IL-6 levels in the case of males could be reduced. Second, this IL-6 exploit could be impeded. Lastly, to hamper the manufacture of IL-6, estrogen-like compounds could be directed. There are organs in the body which are not obviously gender-influenced. On of which is the liver. It is even more astonishing to note that inflammation of the liver is covered up with estrogens. This increases the chance that those organs which were not commonly linked by differences in gender might be administered by a parallel principle.